科研团队

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陈铭

博士
教授

Ming Chen
Professor

 

Email: ming.chen@xmu.edu.cn

个人履历 Brief CV

厦门大学,海洋与地球学院,教授 (2022.1–至今) 
厦门大学,海洋与地球学院,副教授 (2015.4–2021.12)
美国加州大学圣芭芭拉分校,化学/生物工程中心,博士后 (2011.82014.6)  
德国耶拿大学,药剂系,药剂学博士 (2007.92011.5) 
北京大学,药学院,药剂学硕士 (2004.92007.7) 
瑞士Basilea Pharmaceutical AG中国,实验室研究员 (2002.8–2003.8) 
北京大学,药学院, 药学学士 (1998.92002.7)
Professor, Xiamen University, China (2022.1–至今)
Associate Professor, Xiamen University, China (2015.4–2021.12)
Post-Doc, University of California, Santa Barbara, USA(2011.82014.6)
Ph.D. in Pharmaceutics, Friedrich-Schiller-Universität Jena, Germany (2007.92011.5) 
M.Sc. in Pharmaceutics, Peking University, China (2004.92007.7) 
Basilea Pharmaceutical AG,China,Researcher (2002.82003.8) 
B.Sc. in Pharmaceutical sciences, Peking University, China (1998.92002.7)

研究方向 Research Interests

海洋生物医学材料 
经皮给药技术
海洋生物制药 
Marine Biomedical Materials
Skin Drug Delivery
Marine biopharmaceutic

代表性论文 Selected Publications

XueJiao Liang, Jialiang Zhang, HuiLong Ou, Jun,Samir Mitragotri, Ming Chen*.Skin delivery of siRNA using sponge spicules in combination with cationic flexible liposomes. Molecular Therapy - Nucleic Acid. 2020. In press. doi.org/10.1016/j.omtn.2020.04.003
Keda Zhang, Li Yu, Fu-Rong Li, Xue Li, Zhefeng Wang, Xiaoting Zou, Chi Zhang, Kongpeng Lv, Boping Zhou, Samir Mitragotri and Ming Chen*.Topical Application of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Combination with Sponge Spicules for Treatment of Photoaging. International Journal of Nanomedicine. 2020:15,1-14.
XueKe Lin, ZhenHua Wang, Huilong Ou, Samir Mitragotri, Ming Chen*. Correlations between skin barrier integrity and delivery of hydrophilic molecules in the presence of penetration enhancers, Pharmaceutical Research. 2020. doi.org/10.1007/s11095-020-02800-4
Keda Zhang, Wanyang Sun, Alfred Fahr, Xiaobin Zeng,Lanlan Ge, Ming Chen*,Lingzhi Yang, Shipin Wu, Jia Fei and Boping Zhou. Skin-permeating components of Lonicera japonica flos: a comprehensive study from observations and model computations. New J. Chem., 2019, 43, 12538
Chi Zhang, Keda Zhang, Jialiang Zhang, Huilong Ou, Jiwen Duan, Saiman Zhang, Dexiang Wang, Samir Mitragotri, Ming Chen*.Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes. Biomater Sci. 2019 Mar 26;7(4):1299-1310
Xiaobin Zeng, Zhefeng Wang, Xiangli Liu, Ming Chen*, Alfred Fahr and Keda Zhang.Predicting the skin-permeating components of externally-applied medicinal herbs: application of a newly constructed linear free-energy relationship equation for human skin permeation.New J. Chem., 2018, 42, 11930
Saiman Zhang, Huilong Ou, Chunyun Liu, Yuan Zhang, Samir Mitragotri, Dexiang Wang, and Ming Chen*. Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules. Mol. Pharmaceutics 2017, 14, 3188−3200.
Ming Chen, Sunny Kumar, Aaron C. Anselmo, Vivek Gupta, Deborah H. Slee, John A. Muraski, Samir Mitragotri. Topical delivery of Cyclosporine A into the skin using SPACE-peptide. Journal of controlled release, 199 (2015) 190-197.
Ming Chen, Sunny Kumar,Aaron A Anselmo, John A Muraski and Samir Mitragotri,Enhanced Dermal Retention of Topically Applied Steroids using SPACE Peptide. Drug Deliv Transl Res. 2015 May 5. [Epub ahead of print]
Sunny Kumar, Ming Chen, Michael Zakrewsky, Stefano Menegatti, and John A Muraski, Samir Mitragotri. Mechanisms of Peptides as Skin Penetration Enhancers. Journal of controlled release, 199 (2015) 168–178.
M. Chen, M. Zakrewsky, V. Gupta, A.C. Anselmo, D.H. Slee, J.A. Muraski, S. Mitragotri, Topical delivery of siRNA into skin using SPACE-peptide carriers, Journal of controlled release, 179C (2014) 33-41.
M. Chen, V. Gupta, A.C. Anselmo, J.A. Muraski, S. Mitragotri, Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers, Journal of Controlled Release, 173 (2014) 67-74.
Anselmo, A.C., Modery-Pawlowski, C.L., Menegatti, S., Kumar, S., Vogus, D.R., Tian, L.L., Chen, M., Squires, T.M., Gupta, A.S., and Mitragotri, S., "Platelet-like Nanoparticles (PLNs): Engineering Shape, Flexibility and Surface Chemistry of Nanocarriers to Target Vascular Injuries", ACS Nano, Epub (2015).
Zhang K, Chen M, Scriba GK, Abraham MH, Fahr A, Liu X.Human skin permeation of neutral species and ionic species: extended linear free-energy relationship analyses.J Pharm Sci. 2012 Jun;101(6):2034-44.
Haag SF, Chen M, Peters D, Keck CM, Taskoparan B, Fahr A, Teutloff C, Bittl R,Lademann J, Schäfer-Korting M, Meinke MC. Nanostructured lipid carriers as nitroxide depot system measured by electron paramagnetic resonance spectroscopy.Int J Pharm. 2011 Dec 15;421(2):364-9. Epub 2011 Oct 6. PMID:22001533
Haag SF, Fleige E, Chen M, Fahr A, Teutloff C, Bittl R, Lademann J, Schäfer-Korting M, Haag R, Meinke MC. Skin penetration enhancement of core-multishell nanotransporters and invasomes measured by electron paramagnetic resonance spectroscopy. Int J Pharm. 2011 Sep 15;416(1):223-8. Epub 2011 Jul 1.PMID: 21745556
Yang K, Gitter B, Rüger R, Wieland GD, Chen M, Liu X, Albrecht V, Fahr A. Antimicrobial peptide-modified liposomes for bacteria targeted delivery of temoporfin in photodynamicantimicrobial chemotherapy. Photochem Photobiol Sci. 2011 Oct;10(10):1593-601. Epub 2011 Jul 20. PMID: 21773628
Keda Zhang, Ming Chen, Gerhard Scriba, Micheal H. Abraham, Afred Fahr, Xiangli Liu. Linear Solvation Energy Relationship (LSER) Analysis of Retention Factors in Cerasome Electrokinetic Chromatography (EKC). Journal of pharmaceutical science, 2011, Mar 31. doi: 10.1002/jps.22549.
Ming Chen, Xiangli Liu, Alfred Fahr. Skin penetration and deposition of Carboxyfluorescein and Temoporfin from different lipid vesicles: In vitro study with finite and infinite dosage application. International journal of Pharmaceutics, 2011, Vol.408, 223–234.
S. F. Haag, M. Chen, B. Taskoparan, A. Fahr, R. Bittl, C. Teutloff, R. Wenzel, J. Lademann, M. Schäfer-Korting, M. C. Meinke. Stabilization of reactive nitroxides using invasomes to allow prolonged EPR measurements. Skin Pharmacology & Physiology, 2011;24(6):312-21. doi: 10.1159/000330235.
Ming Chen, Xiangli Liu, Alfred Fahr. Skin delivery of ferulic acid from different lipid vesicular systems. Journal of Biomedical Nanotechnology, 2010 Oct; 6(5):577-85.
Liu, X., Fan, P. Chen, M., Hefesha, H., Scriba, G.K.E., Gabel D. & Fahr, A.: Drug -membrane interaction on immobilized liposome chromatography compared to Immobilized Artificial Membrane (IAM), liposome/water, and octan-1-ol/water systems, Helv. Chim. Acta 93, 203-211, 2010
Alfred Fahr, Ming Chen. 2010. Liposomes as Promising Tools for the Skin Delivery and Protection of Damaged Skin, in: Monteiro-Riviere, N.A. (Ed.), Toxicology of the Skin, First ed. informa healthcare.
Chen M, Li XR, Zhou YX, Yang KW, Chen XW, Deng Q, Liu Y, Ren LJ.Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery. Peptides. 2009 Jul; 30(7):1288-95.
Chen M, Deng Q, Li XR, Liu Y.The hypocalcemia effect of salmon calcitonin ultra-flexible liposomes after intranasal administration in rats.Acta Pharmaceutica Sinica. 2007 Jun; 42(6):681-6.